Vitamin D3 (kolekalciferol): 25µg

PMID: 32469224 (VD3 effect on PCOS and ovarian health)

Scientific Description: While primarily known for its role in bone health and regulation of calcium, Vitamin D3 is also involved in the production of reproductive hormones. Deficiency of vitamin D3 is linked to reduced ovarian health and poly-cystic ovarian syndrome (PCOS). Research suggests that vitamin D3 has a beneficial impact on folliculogenesis and steroidogenesis, two biological processes critical to ovarian function.

Magnesium (magnesiumbisglycinate): 150 mg

PMID: 25422352 (Mg and PCOS)
PMID: 9861593 (Mg and PMS)
PMID: 26404370 (Mg supplementation)

Scientific Description: Magnesium supports 300 enzymatic reactions in the body and regulates numerous biological activities across many organ systems. Reduced magnesium levels are linked to reproductive diseases such as poly-cystic ovarian syndrome (PCOS). Research indicated that magnesium supplementation may have a positive impact on insulin sensitivity, cardiovascular health, acute migraines, and premenstrual syndrome (PMS).

Vitamin B6 (pyridoxinhydroklorid): 1.3  mg

PMID: 319288364 (VB6 effect on PMS)
PMID: 21967158 (oral contraceptive effect on VB6)

Scientific Description: Vitamin B6 is an essential nutrient involved in several biological processes including the nervous system, cellular metabolism, and the immune system. Vitamin B6 also influences the endocrine system and the development of reproductive hormones. While some oral contraceptives are reported to negatively impact vitamin B6 levels, vitamin B6 supplementation is demonstrated to improve premenstrual syndrome (PMS) for some women.

Vitamin B12 (methylcobalamin): 2,4 µg

PMID: 33251075 (VB12 and depression)
PMID: 34970669 (VB12 supplementation and PCOS)

Scientific Description: Vitamin B12 is involved in energy metabolism and neurological protection. Deficiency of vitamin B12 is commonly seen in reproductive disorders and hormonal dysregulation. Supplementation with B complex vitamins and folate is documented to improve cardiovascular health in women with PCOS. In addition, research studies report a positive impact of Vitamin B12 supplementation on depression.

Zinc (citrat): 9.4 mg

PMID: 17878022 (Zinc and folate link)
PMID: 32824334

Scientific Description: Zinc plays a crucial role in the immune response as well as the reproductive system and hormone regulation. Researchers document that zinc can improve insulin resistance and lipid balance in women with PCOS. In dysmenorrhea (pain during the menstrual cycle) researchers also determined that zinc supplementation can improve PMS symptoms.

Folate (metyltetrahydrofolat): 400µg

PMID: 34970669 (Folate supplementation and PCOS)
PMID: 17878022, 19443458 (PCOS and folate)

Scientific Description: Folate/folic acid (vitamin B9) is involved in key metabolic reactions supporting antioxidant defense and neuroprotection. PCOS, reduced ovarian health, and infertility are linked to decreased folate levels. Supplementation with B complex vitamins and folate is reported to improve cardiovascular effects in women with PCOS. In addition, researchers noted a beneficial effect of folate on inflammation, oxidative stress, and blood sugar in women with PCOS.

Vitamin C (ascorbic acid): 120 mg

PMID: 15666839 (vitamin C and the adrenal glad)

Scientific Description: Vitamin C has an important role in the adrenal cortex and adrenal medulla, glads that help regulate our hormone (endocrine) system. Deficiencies in magnesium, zinc, B complex vitamins, and vitamin C can negatively impact the HPA axis- a biological pathway critical in our stress response and hormone regulation. 

Vitamin B3 (niacin): 14mg

PMID: 33158037 (niacin)

Scientific Description: Vitamin B3 (niacin) is utilized in numerous cellular activities that are necessary for development and survival. Niacin can also support anti-inflammatory pathways and neuroprotection.